| Image | Actor | Voiced character | GECK voice type ID |
|---|
| | René Auberjonois | Mr. House | CreatureUniqueMrHouse |
| | Laura Bailey | Carrie Boyd, Julie Farkas, Doctor Usanagi, additional voices | FemaleAdult11 |
| | Zoë Bell | Melissa Lewis, Diane, Linda Schuler, Alice Hostetler, additional voices | FemaleAdult06 |
| | John Eric Bentley | Neil, super mutants | CreatureSmartSM |
| | Steve Blum | Harry, Voice 2, additional voices |
| | Suzan Brittan | Keely, Gomorrah bartender, ghouls (female) | FemaleGhoul02 |
| | Emerson Brooks | Major Polatli, Ranger Andy, 10 of Spades, Jean-Baptiste Cutting, Eddie, Sammy Wins, Tyrone, Bryce Anders, Lieutenant Romanowski, Corporal Sterling, Sergeant McCredie, Lieutenant Monroe, Dennis Crocker, Alex Richards, Sgt. Kilborn, Jules, Dermot, Frank Weathers, Jeremy Watson, Johnny, Lee Oliver, Logan, Marco, Ranger Milo, Private Renolds, Ranger Stevens, Troike, additional voices | MaleAdult01DefaultB |
| | Jesse Burch | Private Ackerman, Allen Marks, First Sergeant Astor, Quartermaster Bardon, Sergeant Bitter-Root, Carlyle St. Clair III, Quartermaster Mayes, Clanden, Clayton Ettienne, Ranger Erasmus, Private Halford, Lieutenant Hayes, Jake Erwin, Dr. Kemp, Michael Angelo, Motor-Runner, Driver Nephi, O'Hanrahan, Philippe, Razz, Saint James, Silus, Swank, Jimmy, post-War audio log, Vault 11 narrator, additional voices | MaleAdult03 |
| | Lora Cain | Trudy, Red Lucy, Emily Ortal, Pretty Sarah, Sarah Weintraub, Comm Officer Scheffer, Siri, additional voices | FemaleAdult02 |
| | Jude Ciccolella | Thomas Hildern, Mortimer, Dusty McBride, Johnson Nash, Orion Moreno, Chomps Lewis, Crandon, additional voices | MaleOld01 |
| | Chris Andrew Ciulla | Grecks, Klamath Bob, Norton, Harland, Hadrian, Kyle Edwards, Dennis, ghouls (male), additional voices | MaleAdult12, MaleGenericGhoul |
| | Sam Cohen | Pete, children (male) | MaleChild02 |
| | Rob Corddry | Billy Knight | MaleUniqueBillyKnight |
| | Anthony Crehan | Max, Hector, Forecaster | MaleChild01 |
| | Graham Cuthbertson | Jason Bright | MaleUniqueJasonBright |
| | Felicia Day | Veronica Santangelo | FemaleUniqueVeronica |
| | John Doman | Caesar | MaleUniqueCaesar |
| | Michael Dorn | Marcus | CreatureUniqueMarcus |
| | Robin Atkin Downes | Deputy Beagle, Mister Gutsy, super mutants, additional voices | MaleAdult11 |
| | Dave Foley | Yes Man | RobotYesMan |
| Marc Graue | Keene, Davison, super mutants | CreatureSuperMutant, CreatureLowIntSM |
| | H. Richard Greene | Additional voices |
| | Ian Gregory | Papa Khan | MaleUniquePapaKhan |
| | Michael Hogan | Doc Mitchell | MaleUniqueDocMitchell |
| | James Horan | The King | MaleUniqueTheKing |
| | Shane Johnson | Regis, Oscar Velasco, Old Ben, Canyon Runner, Manny Vargas, Jack, Roy, Mick, additional voices | MaleAdult09 |
| | Paige King | Goodsprings settlers, additional voices | FemaleAdult01Default |
| | Kris Kristofferson | Chief Hanlon | MaleUniqueHanlon |
| | Donna Lynn Leavy | Gamblers (female), travelers (female), additional voices | FemaleOld02 |
| | Mela Lee | Layla, Joana, Ranger Kudlow, Ranger Ericsen, Private Gilbert, additional voices | FemaleAdult09 |
| | Zachary Levi | Arcade Gannon | MaleUniqueArcade |
| | Mitch Lewis | Legate Lanius | MaleUniqueLanius |
| | Yuri Lowenthal | Ringo, Oliver Swanick, Henry Jamison, Nolan McNamara, Lucius, Aurelius of Phoenix, Lars Taggart, Fitz, Keller, Scribe Ibsen, Senior Knight Lorenzo, Ike, Antony, Otho, Alexus, Sergio, Alerio, Sergeant Andrews, Billy Bettis, Daniel, Rick Lancer, Tapper, additional voices | MaleAdult01Default |
| | William Mapother | Colonel Hsu | MaleUniqueColonelHsu |
| | Monte Markham | Aaron Kimball | MaleUniquePresident |
| | Jason Marsden | Craig Boone | MaleUniqueCraigBoone |
| | Gwen McGee | Comm Officer Lenk, Lacey, April Martimer, Ranger Gomez, additional voices | FemaleAdult05 |
| | Ashley McGullam | Melody, Stacey, Atomic Wrangler crier, Mini Boomers (female), New Vegas citizens (female), children (female) | FemaleChild01 |
| | Halston Autumn McMurray | Lindsay, Mini Boomers (female), New Vegas citizens (female), children (female) | FemaleChild02 |
| | Alex Mendoza | Daniel Contreras, Ezekiel, Chavez, Nero, Genaro, Scrambler, Caleb McCaffery, Kenny Weathers, Big Beard, Wayne, additional voices | MaleAdult07 |
| | Dave B. Mitchell | Festus | RobotFestus |
| | Marianne Muellerleile | Daisy Whitman, Ethel Phebus, Jeannie May Crawford, Malefic Maud, Maude, Old Lady Gibson, Pearl, Ruby Nash, New Vegas citizens (female), traveling merchants (female), additional voices | FemaleOld01 |
| | Wayne Newton | Mr. New Vegas | MaleUniqueMrNewVegas |
| | Liam O'Brien | Pacer, Cachino, Jessup, Sergeant McGee, Sergeant Lee, Sergeant Cooper, Major Dhatri, Major Knight, Davey Crenshaw, Lieutenant Gorobets, Captain Parker, Poindexter, Comm Officer Castillo, Comm Officer Tilden, Comm Officer Stepinac, Private Kowalski, Private Sexton, Ranger Pason, Private Stone, Lieutenant Markland, Ranger Grant, Alexander, Isaac, Tomas, James Garret, Ralph, Santiago, Orris, Jacob Hoff, Carlitos, Jerry the Punk, Anders, Ranger Jackson, Dixon, Mr. Soren, Green, Farris, Private Jensen, Little Beard, additional voices | MaleAdult05 |
| | Katherine Pawlak | Sunny Smiles, Ada Straus, Knight Torres, Pauline Wins, Violet, Elizabeth Kieran, Martina Groesbeck, Ranger Stella, Allison Valentine, Meg Reynolds, Rosie, Sylvia, Trash, King groupie, additional voices | FemaleAdult01Default |
| | Ron Perlman | Narrator | MaleUniqueNarrator |
| | Matthew Perry | Benny | MaleUniqueBenny |
| | Diane Pershing | Alice McBride, Alice McLafferty, Marjorie, Mrs. Weathers, travelers (female), additional voices | FemaleOld03 |
| | David Anthony Pizzuto | Lily Bowen | CreatureUniqueLily |
| | Kirsten Potter | Colonel Moore | FemaleUniqueMoore |
| | Cristina Pucelli | Voice 2, additional voices |
| | Rachel Roswell | Rose of Sharon Cassidy | FemaleUniqueCass |
| | Dante Reid | Protectrons, Fisto, Primm Slim, Vendortron | RobotProtectron |
| | Peter Renaday | Doctor Henry, No-bark Noonan, Loyal, Heck Gunderson, Cannibal Johnson, Easy Pete, Walter Phebus, Judah Kreger, Horowitz, additional voices | MaleOld02 |
| | Sam Riegel | Chris Haversam, Andy Scabb, Bert Gunnarsson, Philip Lem, Rotface, additional voices | MaleAdult10, MaleGhoul02 |
| | Cindy Robinson | Francine Garret, Corporal Betsy, Angela Williams, Melissa Watkins, Michelle Kerr, Sammy Weathers, Arms merchant, Street vendor, Trooper Gleeson, additional voices | FemaleAdult07, FemaleAdult12 |
| | Alex Rocco | Big Sal | MaleUniqueBigSal |
| | Ari Rubin | Fantastic, Meyers, Dawes, Little Buster, Miguel, Jack, Argyll, Chet, Ted Gunderson, Dale Barton, Cursor Lucullus, Cato Hostilius, Barton Thorn, Carter, Roller, Weather station guard, additional voices | MaleAdult04 |
| | William Sadler | Victor | RobotVictor |
| | Jason Spisak | Vulpes Inculta | MaleUniqueVulpe |
| | April Stewart | Mags, Lt. Haggerty, Christina Morales, Private Ortega, Ranger Ghost, Tech Sergeant Reyes, Ranger Lineholm, Captain Gilles, Marie Pappas, Raquel, Jacklyn, Liza O'Malley, Doctor Alvarez, Luria, additional voices | FemaleAdult03 |
| | Karen Strassman | Beatrix Russell, Calamity, Followers guard | FemaleGenericGhoul |
| | Fred Tatasciore | Tabitha, Rhonda, Tour guide, PYTHON, Mr. Janitor, Mister Handies | CreatureUniqueTabitha, RobotMisterHandy |
| | Courtenay Taylor | Anne, Gloria Van Graff, Janet, Jas Wilkins, Morgan Blake, Mrs. Hostetler, Lupe, Rachael, Assistant, Boulder City worker | FemaleAdult04 |
| | Andrea Thompson | Dazzle, Lady Jane, card dealer, disguised hookers, hookers (female), additional voices | FemaleAdult08 |
| | Danny Trejo | Raul Tejada | GhoulUniqueRaul |
| | Avery K. Waddell | Malcolm Holmes, Boxcars, Stanton, Simon, Joe Cobb, Hannigan, Samuel Cooke, Dobson, Chauncey, additional voices | MaleAdult02 |
| | Wil Wheaton | Robobrains | RobotRobobrain |
| | Gregory Alan Williams | Bruce Isaac, The Lonesome Drifter, Cliff Briscoe, William Farber, Trent Bascom, Don Hostetler, Cook-Cook, Keith, George, Bill Ronte, Dead Sea, Decanus Severus, Karl, Mister Holdout, Greasy Johnny, Atticus, Blake, Gabban, Samuel Kerr, Squatter Bill, additional voices | MaleAdult06 |
| | Debra Wilson | Boomer teacher, Kate, Sweetie, Yvette, Jackal gang members, New Vegas citizens, Novac settlers, The Tops cashier, Vault 34 dweller, Vikki and Vance dealer, additional voices | FemaleAdult10 |
| | Ron Yuan | Ignacio Rivas, Tommy Torini, Paladin Ramos, Tom Anderson, Ronald Curtis, Mike Lawson, Dr. Whitley, Paladin Sato, Paladin Todd, Destitute traveler, Boulder City workers, additional voices | MaleAdult08 |
